2006 Mercedes-Benz E350 problems, complaints & recalls
Most-reported problem areas: Fuel/Propulsion System (135) · Fuel System, Gasoline (70) · Service Brakes (43)
🧭 Reliability snapshot
Compared against other Mercedes-Benz E350 model years — complaint volume vs the model's median year, recalls and severity. How we score →
🛣️ Complaints by mileage
333 NHTSA complaints that reported an odometer reading.
Safety recalls (4)
Visibility:sun/Moon Roof Assembly 2024-11-19 · campaign 24V874000 · 33,456 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2001-2011 C-Class, CLK, E-Class, and CLS vehicles. Please see the recall report for a complete list of models and model years. The glass sunroof panel may not be properly secured and can detach.
Risk: A detached sunroof panel can become a road hazard, increasing the risk of a crash.
Fix: Dealers will inspect and replace the sunroof panel as necessary, free of charge. Owner notification letters were mailed January 10, 2025. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of previous NHTSA recall number 22V-954. MBUSA's number for this recall is 2024120001/2/3.
Visibility:sun/Moon Roof Assembly 2022-12-23 · campaign 22V954000 · 131,653 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2001-2011 C-Class, CLK, E-Class, and CLS vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The glass sunroof panel may not be properly secured and may detach.
Risk: A detached sunroof panel may become a road hazard, increasing the risk of a crash.
Fix: Dealers will inspect and replace the sunroof panel as necessary free of charge. Owner notification letters were mailed February 3, 2023. Owners may contact MBUSA customer service at 1-800-367-6372. This recall expands NHTSA recall number 19V-918. MBUSA's numbers for this recall are 2023010004, 2023010005, and 2023010006.
Visibility:sun/Moon Roof Assembly 2021-03-19 · campaign 21V196000 · 11,356 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2006-2007 C350, C230, C280, CLK350, E320CDI, E350 Wagon, E350, 2006 C55 AMG, CLK500, CLS500, CLS55 AMG, E500 Wagon, E500, E55 AMG, 2007 CLK550, CLS550, CLS63 AMG, E550, E63 AMG, and E63 Wagon AMG vehicles. The bonding between the glass panel and the sliding roof frame may deteriorate, possibly causing the glass panel to detach from the vehicle.
Risk: A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash.
Fix: MBUSA will notify owners, and dealers will inspect the glass panel bonding and replace the sliding roof, as necessary, free of charge. Owner letters were mailed May 7, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. This recall is an expansion of recall number 19V-918. MBUSA's number for this recall is 2021040012.
Visibility:sun/Moon Roof Assembly 2019-12-20 · campaign 19V918000 · 747,928 vehicles
Defect: Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2001-2011 vehicles. The bonding between the glass panel and the sliding roof frame may deteriorate, possibly resulting in the glass panel detaching from the vehicle. For a full list of the affected models visit: https://static.nhtsa.gov/odi/rcl/2019/RMISC-19V918-4126.pdf
Risk: A detached glass panel can separate from the vehicle and become a road hazard, increasing the risk of a crash.
Fix: MBUSA will notify owners, and dealers will inspect the glass panel bonding and replace the sliding roof, as necessary, free of charge. The recall began July 10, 2020. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2020040011.
Service bulletins (116)
Technical service bulletins are repair instructions manufacturers send dealers for known issues. Unlike recalls, the fix is not automatically free — but naming the bulletin at the service desk can save diagnosis time and support goodwill repairs.
Service Brakes 2026-09-22 · LI42.10-P-078779 · Service Bulletin/Repair Instructions
complaint repeat workshop visit for vehicle vibration while braking from 60mph. note: although the symptom is similar to a tire or wheel vibration, it is usually readily noticeable that it is distinctly different if it happens at all times or only while braking. cause although the cause of the vibra
Structure:body 2026-09-14 · LI82.62-P-078631 · Service Bulletin/Repair Instructions
complaint clanking noise from the area of the speakers in the doors. cause under analysis. remedy to narrow down the cause, first of all remove the door trim. • if the noise continues to occur even with the door trim removed, then continue the diagnosis working towards the speaker and if necessary,
Structure:body 2026-08-06 · LI82.62-P-078631 · Service Bulletin/Repair Instructions
complaint clanking noise from the area of the speakers in the doors. cause under analysis. remedy to narrow down the cause, first of all remove the door trim. • if the noise continues to occur even with the door trim removed, then continue the diagnosis working towards the speaker and if necessary,
Power Train 2026-07-14 · LI35.30-P-058566 · Service Bulletin/Repair Instructions
single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end). the noise is heard once in each instance when changing direction of travel. note: sound file in attachment cause if the complaint is eliminated by experimentally loosening the outboard collar n
Visibility/Wiper 2026-05-19 · LI82.30-P-059239 · Service Bulletin/Repair Instructions
complaint there are several types of complaint about noises or poor windshield wiper wiping performance: a: wiper blades squeaking, chattering, shuddering b: the windshield is not wiped completely (streaking) c: during the downward movement water is pulled back onto the windshield from the a-pillar
Visibility/Wiper 2026-04-25 · PSL-NCU Return Parts 4/24 · Other
the part numbers listed in the chart below should no longer be installed, and any existing stock must be returned to your facing pdc. the deadline for all dealer returns is no later than thursday, may 14, 2026. after may 14th, returns of these parts will no longer be accepted. these parts should be
Showing the 6 most recent of 116 bulletins. Search all of them free at nhtsa.gov.
What owners report
2026-10-15 · Service Brakes, Hydraulic · 151,000 mi“the contact owns a 2006 mercedes-benz e350. while driving at 30 mph, a "reduced braking power" warning message was displayed on the instrument panel followed by an audible alarm. the brake pedal travelled to the floorboard, resulting in a significant loss of braking functionality. additionally, the vehicle became stuck in second gear, requiring the…”
2026-09-23 · Service Brakes, Hydraulic · 152,786 mi“the contact owns a 2006 mercedes-benz e-350. the contact stated that the sensotronic brake control warning was illuminated. the contact researched and found information about warranty coverage for 2006-2010 models with a 25-year warranty. the vehicle was taken to the dealer, who diagnosed that the main battery needed to be replaced but had not prov…”
2025-12-03 · Service Brakes“mercedes benz issued a recall and extended a warranty on its 2003-2005 e class sbc braking systems (recall # 2005110001) and extended the warranty to 25 years; the 2006 e class models have the exact same sbc braking system but is not included in the recall. mercedes needs to add the 2006 e class models to recall # 2005110001. my 2006 is experiencin…”
2025-10-23 · Service Brakes, Hydraulic · 180,000 mi“the contact called on behalf of the owner of a 2006 mercedes-benz e350. the contact stated that while his mother was driving at an undisclosed speed and approaching a traffic light, the brake pedal was depressed; however, the brakes failed to function as intended. the brake pedal was depressed down to the floorboard. the contact's mother used the p…”
2025-10-21 · Visibility · 97,900 mi“the contact's son owns a 2006 mercedes-benz e350. the contact stated that while his son was driving at an undisclosed speed, the sunroof detached and shattered on the roadway. the vehicle was not taken to the dealer or an independent mechanic. the vehicle was not repaired. after investigating the failure, the contact related the failure to nhtsa ca…”
2025-05-30 · Unknown Or Other“reduce power braking depress brake fully keeps popping up on my dash and not letting me take it out of gear …”
2024-08-29 · Vehicle Speed Control“the engine in these cars are defective and can cause serious harm due to a part that was put inside the motor made of plastic. there was a lawsuit but if you didn’t get in on it you losses out for not knowing. i was recently at mercedes dealership to fix recalls and they brushed me off. the car can catch fire and i’m already experiencing engine fai…”
2024-03-21 · Service Brakes · 149,000 mi“the contact owns a 2006 mercedes-benz e350. the contact stated while driving at 35 mph, the vehicle would not stop when depressing the brake pedal. no warning lights were illuminated, however, the contact stated the entire instrument panel was illuminated in red. the vehicle was taken to a local independent mechanic where the vehicle's brake line…”
2024-02-05 · Service Brakes, Hydraulic · 177,000 mi“the contact owns a 2006 mercedes-benz e350. the contact stated that upon depressing the brake pedal, there was a beeping sound coming from the vehicle with a message stating "stop, reduced braking power, depress brake pedal fully" displayed on the instrument panel. the contact pulled over to shoulder of the road. due to the failure, the vehicle was…”
2023-12-30 · Engine“certain mercedes-benz models 2005- 2007 m272 v6 and m273 v8’s have faced or are facing issues regarding the balance sprocket in which drives the camshaft and crankshaft of the vehicle. mercedes-benz had made a decision to make certain engine components out of soft metals, when such metals are not adequate in handling the stress of the engine. in pa…”
Excerpts of consumer complaints filed with NHTSA, lightly truncated. They are owner statements, not verified findings.