2021 Mercedes-Benz E 350 problems, complaints & recalls
Most-reported problem areas: Power Train (3) · Engine (3) · Fuel/Propulsion System (2)
🧭 Reliability snapshot
Compared against other Mercedes-Benz E 350 model years — complaint volume vs the model's median year, recalls and severity. How we score →
Safety recalls (12)
Fuel System, Gasoline:delivery:fuel Pump 2023-06-26 · campaign 23V445000 · 143,551 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.
Risk: A loss of drive power can increase the risk of a crash.
Fix: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.
Electrical System:software 2022-05-20 · campaign 22V365000 · 242,722 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. An error in the communication module's SIM card software can cause a mobile network connection failure, disabling the emergency call (eCall) system.
Risk: A disabled eCall system would prevent a vehicle occupant from contacting the emergency services call center in an emergency, potentially delaying emergency responders and increasing the risk of injury.
Fix: The communication module software will be updated through an Over-the-Air (OTA) update or by a dealer, free of charge. Owner notification letters were mailed July 8, 2022. Owner notification letters will be mailed in phases, on July 8, 2022, May 17, 2024, July 29, 2024, and September 27, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's numbers are for this recall is 2022060005 and 2023110006.
Back Over Prevention:display Function 2022-04-08 · campaign 22V232000 · 126,443 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2018-2021 CLA-Class, GLE/GLS-Class, A-Class, C-Class, E-Class, E-Class Coupe/Convertible, GLA/GLB-Class, GLC-Class, and CLS-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The rearview camera may not display the rearview image due to a software error. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 111, "Rear Visibility."
Risk: An inoperable rearview camera display reduces the driver's rear view, increasing the risk of a crash.
Fix: Dealers will update the rearview camera software, free of charge. Owner notification letters were mailed July 15, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022060007.
Steering: Steering Wheel/Handle Bar 2022-03-25 · campaign 22V189000 · 8,396 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel. Due to a software error in the hand detection control unit, the hands-off detection might not detect when the driver's hands are away from the steering wheel when using the Active Distance Assist DISTRONIC system.
Risk: Deactivated hands-off detection will prevent DISTRONIC system features from functioning, including warnings to grab the steering wheel and calling first responders as part of the Active Emergency Stop Assist, which can increase the risk of a crash or injury.
Fix: Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022040010.
Air Bags:sensor:side Impact 2021-07-12 · campaign 21V527000 · 542 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 CLS450, AMG E53, AMG CLS53, E350, E450, AMG GT43, AMG GT53, 2020 S450, S560, G550, AMG GLC63, 2020-2021 GLC300, and AMG G63 vehicles. The side crash sensor connectors may come loose, which could delay the activation of air bags and seatbelts during a side impact crash.
Risk: Air bags and seatbelts that don't function as intended can increase the risk of injury during a crash.
Fix: Dealers will inspect and replace as necessary, the side impact crash sensors, free of charge. Owner notification letters were mailed on September 3, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021070032/33.
Seat Belts:rear/Other:retractor 2021-06-25 · campaign 21V483000 · 4,917 vehicles
Defect: Mercedes-Benz, LLC (MBUSA) is recalling certain 2021 G550, AMG G63, E350, E450, AMG CLS53, AMG E53, AMG GT43, AMG GT53, AMG GT63, 2021-2022 CLS450, and AMG E63 vehicles. The rear seat belt automatic locking retractors may deactivate early, which can prevent the child restraint system from securing properly. As such, these vehicles fail to comply with the requirements of Federal Motor Vehicle Safety Standard number 208, "Occupant Crash Protection."
Risk: An unsecured child restraint system can increase the risk of injury during a crash.
Fix: Dealers will inspect, and replace as necessary, the rear seat belt assemblies, free of charge. Owners notified of the voluntary recall campaign by an interim letter on August 13, 2021. A final letter was mailed on September 24, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.
Back Over Prevention: Sensing System: Camera 2021-05-14 · campaign 21V354000 · 343,191 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLA-Class, GLE/GLS-Class, A-Class, E-Class, E-Class Coupe and Convertible, GLA/GLB-Class, GLC-Class, CLS-Class, and AMG GT-Class 4-door Coupe vehicles. Please refer to MBUSA's recall report for specific vehicle model details. The MBUX multimedia system software may cause the display to remain black, or reboot after startup. This could result in the rearview camera image not displaying properly. As such, these vehicles fail to comp
Risk: A backup camera that displays a blank image reduces the driver's rear view, increasing the risk of a crash or injury.
Fix: The multimedia system software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. Owner notification letters were mailed beginning June 28, 2021. Owners may contact MBUSA customer service at 1-800-367-6373. MBUSA's number for this recall is 2021050012.
Back Over Prevention:warnings:external/Pedestrian Alert 2021-04-01 · campaign 21V228000 · 6 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, and AMG E63 vehicles. The parking control unit may fail to display the rearview camera image and cause the parking sensors to misidentify or fail to detect objects.
Risk: An inoperative rearview camera display and/or parking sensors can reduce the driver's view and awareness of what is behind the vehicle, increasing the risk of a crash.
Fix: All affected vehicles are still within MBUSA's control. MBUSA will replace the parking control unit, free of charge. The recall began April 8, 2021. Owner may contact MBUSA customer service at 1-800-367-6372.
Seat Belts:pretensioner 2021-04-01 · campaign 21V230000 · 8,634 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 C-Class, E-Class, E-Class Coupe and Convertible, GLC, CLS, AMG GT 4-door Coupe and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details. A faulty electrical contact within the seat position switch may prevent the driver and passenger air bags and seat belt force limiters from properly activating during a crash.
Risk: Air bags and seat belts that do not perform properly in a crash can increase the risk of injury.
Fix: MBUSA will notify owners, and dealers will replace the seat position switches, free of charge. Owner letters were mailed May 21, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040016.
Seats:front Assembly:power Adjust 2021-03-26 · campaign 21V216000 · 109 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, E63S AMG, 2020 E63S AMG Wagon, and 2020-2021 E53 AMG vehicles. The passenger seat limiter may allow the seat to be positioned too close to the air bag.
Risk: A seat too close to the air bag increases the risk of injury in the event of a crash necessitating the deployment of the frontal passenger air bag.
Fix: MBUSA will notify owners, and dealers will recalibrate the passenger seat limiter, free of charge. The recall began April 29, 2021. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2021040002.
Communication: Auto Crash Notification 2021-02-05 · campaign 21V058000 · 1,292,258 vehicles
Defect: Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2016 - 2021 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, GT-Class, C-Class, E-Class, S-Class, CLS-Class, SL-Class, B-Class, GLB-Class, GLC-Class, and G-Class vehicles. Please refer to the Part 573 report for specific vehicle model details. The software design of the communication module may fail to communicate the correct vehicle location for the emergency call system (eCall) in the event of a crash.
Risk: Failure of the eCall system may result in emergency responders being dispatched to the wrong location, increasing the risk of injury following a crash.
Fix: MBUSA will notify owners, and the communication module software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. The recall began March 12, 2021. Owners may contact MBUSA customer service at 1-877-762-8267. MBUSA's number for this recall is 2021020025.
Seats 2020-10-30 · campaign 20V673000 · 1,337 vehicles
Defect: Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2021 E350 and E450, 2019-2021 AMG E53 and 2020-2021 AMG E63 vehicles. The front passenger seat may be missing the mechanical seat adjustment range limit stop, allowing the seat to move outside of the acceptable range in relation to the air bag.
Risk: If the front passenger seat is adjusted beyond the acceptable range in relation to the air bag, there could be an increased risk of injury in the event of a crash with air bag deployment.
Fix: MBUSA will notify owners, and dealers will inspect for the mechanical seat adjustment range limitation for the front passenger seat and install it if necessary, free of charge. The recall began December 18, 2020. Owners may contact MBUSA customer service at 1-800-368-6372. MBUSA's number for this recall is 2020110013.
Service bulletins (213)
Technical service bulletins are repair instructions manufacturers send dealers for known issues. Unlike recalls, the fix is not automatically free — but naming the bulletin at the service desk can save diagnosis time and support goodwill repairs.
Steering 2026-09-26 · LI46.10-P-080896 · Service Bulletin/Repair Instructions
complaint slight creaking noises when steering. cause noises may come from one or more sleeves of the horn contact plate. remedy remove the horn contact plate and check the sleeves for noise; see attached video. if necessary, apply lubricant to the sleeves.
Power Train 2026-09-26 · LI27.00-P-073124 · Service Bulletin/Repair Instructions
complaint customer complaints relating to automatic transmission 725.0 (nag3 classic /9g‑tronic automatic transmission) and 725.1 (nag3 facelift/9g‑tronic automatic transmission facelift) for faster, more effective and more targeted diagnosis, intelligent predictive repair (ipr) has been developed a
Service Brakes 2026-09-22 · LI42.10-P-078779 · Service Bulletin/Repair Instructions
complaint repeat workshop visit for vehicle vibration while braking from 60mph. note: although the symptom is similar to a tire or wheel vibration, it is usually readily noticeable that it is distinctly different if it happens at all times or only while braking. cause although the cause of the vibra
Engine 2026-09-17 · LI20.10-P-075374 · Service Bulletin/Repair Instructions
complaint red coolant warning in instrument cluster. fault codes u019f00 or u019f87 current/stored in mrg1 control unit. cause various causes remedy perform guided test for fault code u019f with xentry diagnosis. verify the following connections are clean and tight. correct any problems and retest p
Structure:body 2026-09-14 · LI82.62-P-078631 · Service Bulletin/Repair Instructions
complaint clanking noise from the area of the speakers in the doors. cause under analysis. remedy to narrow down the cause, first of all remove the door trim. • if the noise continues to occur even with the door trim removed, then continue the diagnosis working towards the speaker and if necessary,
Power Train 2026-09-14 · LI27.10-P-075869 · Service Bulletin/Repair Instructions
complaint only vehicles with a variable transfer case are affected. this can be identified through control unit n45 or n15/7 in the quick test. when accelerating with light load, vibrations or jolting sensation may come from the drivetrain. it may be mistaken for a harsh shift. cause modified oil qu
Showing the 6 most recent of 213 bulletins. Search all of them free at nhtsa.gov.
What owners report
2026-08-08 · Power Train“engine misfires, lower engine power, and a lit check engine/malfunction indicator lamp. mercedes-benz issued an emission service campaign (no. 2021070006, internal code 21p1590208) to replace out-of-spec ignition coils on 657 vehicles from model year 2021, including the e-class. my vin was not included in the recall campaign but my vehicle is exper…”
2026-05-08 · Fuel/Propulsion System“vehicle: 2021 mercedes-benz e350 sedan (w213) vin: [xxx] while operating the vehicle, the diagnostic system displayed the fault code p240200 related to the evaporative emission control system (evap). the warning message indicated a “positive short circuit” in the fuel vapor leak diagnosis pump control circuit. the malfunction appears to involve t…”
2026-01-04 · Power Train“with the car only have about 15,000 miles the transmission has failed . i have seen there have been recalls of other models with similar complaints of transmission failure . …”
2025-12-27 · Engine“engine keeps having a misfire that mercedes put a tsb out for and once the misfire happen i cause the vehicle to go in a limp mode which causes the vehicle to loose power happened to me in the freeway. the car had 54k miles and mercedes refused to repair the issue as the engine part failure isn’t common.…”
2025-07-14 · Engine“my 2021 mercedes-benz e350 (vin [xxx] ) developed a serious engine issue involving cylinder misfire and check engine light. the dealer diagnosed it as a leaking exhaust valve on cylinder 4, related to tsb li01.30-p-072328, which documents valve seat wear in m260 engines. this is a known defect acknowledged by mercedes in technical bulletins, and o…”
2025-07-10 · Power Train“the mercedes e350, with 22,000 miles suffered a catastrophic transmission failure while driving on the highway. i managed to exit the highway but the car could not be moved and left me stranded. …”
2025-03-21 · Electrical System“1) rear view camera sometimes working, some times not working. (message reads “system inoperative “ 2) forward view camera also affected. 3) display shown “12v battery low in battery “ 4) not long ago, just had vehicle suddenly vibrating vigorously while backing up from parking and during driving. gas paddle not responding when stepping down,…”
2024-12-07 · Engine · 🔥 fire“fire fire fire information light came on just saying 12 volt battery. i sat in the car letting it idle for about 3 minutes. it began to smoke and then burst into flames. i called 911 got the fire department here but by the time they were here there was not much left. the car essentially burned to the ground and insurance has declared it a total…”
2024-05-18 · Back Over Prevention: Warnings“i was parking and the 360 view sensor did not come up. when i tried to back out and move forward again, i realized the back up camera would not come on. i turned the car on and off and then tried again to reverse to engage the camera but was instead given a message that says system inoperative. …”
2024-03-22 · Service Brakes · 24,001 mi“the contact owns a 2021 mercedes-benz e350. the contact stated that while parking the vehicle the emergency brake independently seized. the contact stated that the vehicle abruptly stopped. the vehicle would not drive forward or backward. the contact contacted the dealer and a service technician was dispatched to the location. the service techn…”
Excerpts of consumer complaints filed with NHTSA, lightly truncated. They are owner statements, not verified findings.